What does this estradiol topical cream do?
This cream delivers bioidentical estradiol (the same estrogen your body makes) through your skin and into your bloodstream. It helps relieve menopause symptoms like hot flashes, night sweats, and mood swings. It also helps support bone health and may improve sleep and energy.
What is the benefit to a topical cream?
Transdermal/topical estrogen does not increase the risk of blood clots to the same degree as oral estrogens, making it a preferred option for patients with controlled hypertension or higher Body Mass Index (BMI). It also offers an alternative for women with adhesive allergies or skin irritation from patches, and allows for flexible dosing not always available in commercial products.
How do I apply it?
- Prime: If it’s a new pump, press it a few times until cream comes out.
- Dispense: Push the pump all the way down for your exact dose.
- Spread: Rub into a thin layer until absorbed (about the size of two silver dollars).
- The “One-Hour Rule”:
- Do not wash the area for at least 1 hour after applying.
- Cover the area with clothing to prevent transfer to partners, children, or pets.
- Clean up: Wash your hands right away with soap and water to avoid transferring the hormone to others.
When should I use it?
Apply at the same time every day to keep hormone levels steady. Morning works well for many women, but consistency matters most.
Where should I apply it?
Apply to clean, dry skin on your inner thighs or inner forearms. Do not apply to your breasts or genital area, as this can change absorption.
Should I apply it to the same place every day?
Rotate sides each day to prevent irritation.
Can I use it with other skincare products?
Yes, but don’t apply them at the same time or on the same spot. Wait at least 20–30 minutes before putting lotions, oils, or creams on that area.
Should I apply it before or after sunscreen?
Apply estradiol cream first. Let it dry completely (wait 20–30 minutes) before applying sunscreen. Sunscreen can block absorption if applied too soon.
What results can I expect? When can I expect them?
- 1–2 weeks: Hot flashes and sleep may improve.
- 4–8 weeks: Full benefits for mood and brain fog.
- Long term: Helps protect bone density and heart health.
Is it suitable for all skin types?
Yes, the cream base is usually well tolerated. If you have very sensitive skin or eczema, test a small area first. Contact your primary care provider if you develop a lasting rash.
Can I use it while pregnant or breastfeeding?
Do not use during pregnancy. If breastfeeding, talk to your Midi clinician.
What if it gets in my eyes?
Rinse your eyes right away with lukewarm water for several minutes. Contact your primary care provider or emergency services if irritation continues.
How should I store it?
- Store at room temperature in a dry place
- Avoid steamy bathrooms
- Keep the cap tightly closed
- Keep out of reach of children and pets (the cream can be absorbed through skin)
Can I use this product with an estradiol patch?
Talk to your Midi clinician before combining this cream with a patch or any other estradiol product.